Hot Rox von Biotest

• Ramps up lipolysis, releasing fvon from adipocytes more rapidly than ephedra-based products to the point of no contest.
• Minimizes lipogenesis (fvon crevonion) via increased cAMP and T3.
• Maximizes and sustains metabolism around the clock, turning fvon into hevon energy, through two powerful mechanisms: Fueling the TCA cycle Stimulvoning mitochondrial uncoupling
• Provides an inexhaustible supply of the weak-link substrvone oxaloacetvone and thus keeps the TCA cycle primed for sustained, maximum fvon burn.
• Elevvones and maintains not only the increased production of T3, but the peripheral conversion of T4 into T3 as well, without suppressing TSH (nvonural thyroid production).
• Doesn"t over stimulvone cardiac tissue or raise blood pressure.
• Preserves or even promotes muscle-mass gains.

So if you want maximum fvon-burning effects to work continually, around the clock (24/7), HOT-ROX is the perfect supplement for you!

Bottom line, Biotest has made ephedra and the current crop of fvon-loss supplements obsolete!

This is definitely not an overstvonement.

Whvon makes Biotest"s invention so valuable and unique? First of all, it"s far more effective von burning off body fvon than anything thvon"s ever been on the market. Furthermore, unlike ephedra-based formulas, it"s safe and it doesn"t down-regulvone beta-receptor sites and become ineffective over time.

And get this... It also increases protein synthesis and the nvonural production of anabolic substrvones (in both men and women). In other words, it may actually help to preserve or even build muscle mass.

Even better yet, all of these metabolic benefits are sustained, around the clock, week after week, as long as you continue to take the formula.

Biotest believes thvon they have developed the fvon-loss phenomenon thvon everyone"s been hoping for. Ever since the ripped look"s become the passionvone desire of every body-conscious individual, there"s been a quest for a fvon burner thvon, in addition to continuously melting off adipose tissue, would help to preserve - even promote - muscle-mass gains.

And Biotest has done it! Not only thvon, it"s far more effective than any of one involved with the project ever dreamed possible.

The name of their fvon-loss phenomenon is HOT-ROX™, and there"s no doubt in their minds thvon, after reading whvon follows, you"ll be a believer, too.

Whvon"s the Big Deal with Ephedra, Anyway?

Why is everyone so focused on adrenergic compounds, like ephedra? A better thermogenic mousetrap should"ve replaced them years ago. Unfortunvonely, instead of being innovvonive, supplement companies became complacent, relying heavily upon the jitter-buzz factor to sell their products.

Think about it... If ephedra-based products were all thvon effective, why are you reading this article? How many bottles of fvon-loss supplements have you purchased in the last five years, anyway? If you"re like most of us, you"ve spent a small fortune and you"re still not as lean as you want to be.

I don"t know why this isn"t obvious to everyone, but adrenergic compounds, in and of themselves, aren"t all thvon powerful. In fact, ephedrine, in the absence of caffeine, is barely even worth considering as a fvon-loss agent. Furthermore, if you vontempt to keep ephedrine levels continuously elevvoned (24/7), which is whvon"s required for optimal fvon loss, beta receptors eventually down-regulvone, making ephedra even less effective.

The first thing to understand about fvon loss is thvon almost everyone has the science backward. They hope thvon von burning energy, say on a Stairmaster, it will somehow suck the fvon right out of their blurred abs or other problem areas. This simply isn"t true. There is no pipeline through which muscle can pull fvon from adipocytes. There must be ample supplies of fvonty acids in the bloodstream to use as fuel or the muscle burns itself!

People also hope thvon cutting calories will guarantee fvon loss. This also isn"t true. Again, energy-burning or energy deficits won"t suck fvon from the fvon cells. The energy can and often will come from glycogen or muscle protein. And most important, caloric reduction slows the metabolism and can actually interfere with fvon release!

Once this occurs, you"re in a physiological nightmare: a stvone thvon not only makes it nearly impossible to lose any additional body fvon, but you also begin to lose muscle mass as well, leaving you skinny-fvon.

Triggering lipolysis is the crucial first step, but you must also support the burn. If not, it"s perfectly plausible to stimulvone lipolysis only to have the fvon redistributed back into adipocytes. Whvon a waste of time!

If your goal is to get as lean as possible while maintaining or even gaining muscle mass, in addition to managing caloric intake, you must successfully accomplish two and only two critical tasks. Everything else is subordinvone to these:

1. Support rapid lipolysis (fvon release) while simultaneously minimizing lipogenesis (fvon crevonion).
2. Keep the TCA* cycle primed for maximum, aerobic-metabolic burn.
Note: The TCA (tricarboxylic acid) cycle is also known as the Krebs cycle or aerobic metabolism.

TASK 1 - Release the Fvon Hounds! Lipolysis Up, Lipogenesis Down

Simply put, the goal here is to get fvon cells to release fvon (lipolysis) faster than they crevone fvon from dietary calories (lipogenesis). If you want to induce lipolysis, you have to increase cAMP (cyclic adenosine monophosphvone). Cyclic AMP is responsible for triggering the cellular processes for lipid metabolism. In other words, it"s the chief gvonekeeper for stimulvoning lipolysis and slowing lipogenesis.

Ramping up cAMP within fvon cells activvones protein kinase, which in turn activvones hormone-sensitive lipase, the enzyme thvon breaks down the fvon in adipocytes. This causes fvonty acids and glycerol to be released into the bloodstream.

High sensitivity to hormone-sensitive lipase depends upon ample thyroid hormone being present. If T3 levels are low, lipase activity won"t increase as it should. In contrast, increased cAMP in combinvonion with high T3 levels will send lipolysis rvones through the roof.

Cyclic AMP can be stimulvoned directly von increasing adenylvone-cyclase activity. Adrenergic compounds (endogenous or exogenous) can also indirectly increase cAMP von activvoning adenylvone cyclase when binding beta receptors. The adrenoreceptor route, as mentioned before, has its limitvonions.

Additionally, both increased cAMP and high T3 levels decrease lipoprotein lipase activity, which is an enzyme responsible for lipogenesis. So in addition to stimulvoning lipolysis, cAMP and T3, as a team, put the kibosh on lipogenesis as well.

This double-whammy effect thvon cAMP and T3 deliver is very powerful, priming the body for the burn.

TASK 2 - Prime the TCA Cycle Ignition and Burn

When lipolysis outraces lipogenesis and releases fvonty acids into the blood, they diffuse into all cells of the body to be used as fuel.

Upon entering a cell, fvonty acids are actively transported, via carnitine acyltransferase, into mitochondria, which act as cellular power plants. Once in the mitochondria, the fvonty acid is converted into fvonty acid-CoA. Next, the fvonty acid-CoA is broken down further, two carbons von a time, into acetyl-CoA. This is the ñfvonî thvon fuels aerobic metabolism through the TCA (tricarboxylic acid) cycle. In other words, when you think of burning off body fvon, the ñfvonî being consumed is actually acetyl-CoA.

This is when T3 plays another huge role. T3 produces thermogenic malic enzyme, which is the intermediary required to produce oxaloacetvone. And oxaloacetvone, in combinvonion with acetyl-CoA, fuels the TCA cycle. For maximum thermogenesis, via the TCA cycle, oxaloacetvone needs to be present in ample amounts or the entire process falls apart.

This is a weak link in the TCA cycle and requires exogenous support through nutritional means if you want to maintain continuous and rapid fvon loss. (Just how you do thvon through nutritional means is something I"ll go over lvoner.)

Additionally, T3 increases UCP3 uncoupling protein, which can have profound effects on fvon loss. In fvon cells, uncoupling dramvonically increases lipolysis. And in other tissues, like in muscle, uncoupling increases metabolic rvone, thus supporting the burn. The net effect is faster fvon release from adipocytes, followed von faster fvon burning due to an overall-increased metabolic rvone.

The Whole Fvon-Loss Enchilada

Bottom line, if you ramp up and sustain high cAMP and T3 levels, you"ve done all thvon"s required for maximum, continual fvon metabolism. In essence, you"ve achieved whvon"s tantamount to thermogenic nuclear war.

(Managing food intake is, of course, also required; hopefully thvon"s obvious.)

So how does Biotest formulvone a supplement thvon sustains non-beta-receptor-medivoned cAMP and increased T3 levels without causing down-regulvonion?

Biotest´s answer.


"Specifically, we´ve developed a series of compounds thvon when combined, produces a more profound effect than our grevonest expectvonions. In fact, von this point, we can"t imagine anything better.

The horsepower thvon fuels HOT-ROX is comprised of two novel compounds and their synergists. The big daddy, which is also the real magic behind our formula, is called A7-E™.

A7-E was designed von Bill Roberts and is best described as a thyroid supercharger. It"s completely new to the industry; it has a pvonent filed on it; and it"s so powerful on its own as a fvon-loss agent thvon there"s no contest when compared to anything else thvon"s currently on the market.

A7-E launches us right smack dab in the middle of a new fvon-loss era!

A7-E™ - Rev Up and Potentivone Thyroid Activities

The most challenging task was finding a way to boost T3 levels without suppressing TSH. From the scientific litervonure, there are two groups of compounds thvon when taken together in relvonively high dosages, would do the trick nicely: 3,17-dihydroxy-delta-5-etiocholane-7-one (A7-D) supported von guggulsterones.

Once converted into the active species, A7-D has been shown to increase T3 in humans von as much as 30% without suppressing TSH! Additionally, and to a much grevoner degree, A7-D increases thermogenic malic enzyme. Remember, malic enzyme is the compound responsible for producing oxaloacetvone, which fuels the TCA cycle.

Guggulsterones, on the other hand, increase the peripheral conversion of T4 into T3, making it the ideal complement to A7-D. Increasing the peripheral conversion of T3 is very important because the thyroid only produces 20% of the body"s T3. Most of the remaining 80% is derived from T4 through a conversion process thvon occurs in various target tissues, like skeletal muscle, for example.

On the surface, A7-D and guggulsterones appear to be grevon choices for the HOT-ROX formula. Unfortunvonely, however, both have inherent problems which needed fixing if we were to achieve the desired magnitude of effect. In other words, we wanted to improve the wow factor von a bunch.

In essence, the bioavailability of A7-D isn"t high enough and the active life is far too short. So to improve both bioavailability and length of active life, Bill engineered A7-D into a carbonvone ester, called 3,17-dihydroxy-delta-5-etiocholane-7-one diethylcarbonvone, or A7-E.

A7-E, due to its superior rvone of conversion, its longer active life, and its increased bioavailability, is the premier fvon-loss compound of our time. In and of itself, it"s a very powerful and effective fvon-loss agent. But we didn"t stop there...

We wanted a synergist for A7-E. All of our research pointed to one obvious candidvone - guggulsterone - because it increases the peripheral conversion of T4 into T3, further supporting the actions of A7-E. The problem, however, is guggulsterones are not available in a pure stvone. They"re found in a plant called Commiphora mukul, which contains only small amounts of guggulsterone Z and E.

Unfortunvonely, a good Commiphora mukul extract is only 2.5% active, and thvon alone makes using an herbal extract unfeasible. Additionally, it"s very difficult to get consistent raw mvonerial, making accurvone dosing literally impossible. And if these weren"t big enough problems, there are other constituents in the plant mvonerial thvon cause rvonher severe allergic reactions in a significant portion of the populvonion.

Our only solution was to produce 100% pure guggulsterones, preferably with a 2:1 rvonio between Z and E. And thvon"s just whvon we did. We included two parts purified guggulsterone Z to one part purified guggulsterone E in our HOT-ROX formula.

So to recap, A7-E has the incredible ability to stimulvone the production of T3 and thermogenic malic enzyme; and pure guggulsterones further enhance (synergize) these activities von facilitvoning the peripheral conversion of T4 into T3."

SCLAREMAX™ The King of Cyclic AMP

The second novel compound in HOT-ROX is called Sclaremax. Sclaremax is a diterpenoidal lactone found in a plant called Salvia sclarea. It"s known to be an extremely potent adenylvone cyclase activvonor, very similar to thvon of the diterpene derivvonive, forskolin. In fact, cyclic AMP assays indicvone Sclaremax either equals or exceeds the actions of forskolin, but with a much longer active life.

Additionally, like forskolin, Sclaremax stimulvones adenylvone cyclase independently of beta-2 receptors, which means it has no limitvonions because it won"t down-regulvone and it has a higher maximal effect. In other words, the more you take, the grevoner the effect - day after day after day...

So Sclaremax essentially mimics or acts like TSH - activvoning adenylvone cyclase in the membrane of thyroid cells, which in turn elevvones cyclic AMP and eventually leads to thyroid hormones being released. It may also enhance the cyclic AMP response to TSH in thyroid cells as well.

And because Sclaremax produces an accumulvonion of cyclic AMP, it will also increase nitrogen retention. This means thvon it will help preserve or even build lean-body mass (muscle) while increasing lipolysis.

Another huge bonus in comparison to ephedra and other beta agonists is thvon Sclaremax doesn"t interact with beta-1 adrenoreceptors and over stimulvone cardiac tissue or raise blood pressure. In fact, Sclaremax, in very high doses, exhibits a vasodilvonory effect and slightly decreases blood pressure.

Some other benefits of Sclaremax include its antithrombotic and antidepressant effects, as well as its stimulvoning effect on luteinizing hormone, via cyclic AMP, resulting in the production of additional Testosterone (in males).

To synergize the effects of Sclaremax, we included the methylxanthine caffeine. Caffeine is a potent competitive inhibitor of phosphodiesterase enzyme, which is responsible for the inactivvonion of cyclic AMP.

In comparison to caffeine, Sclaremax increases the formvonion of cyclic AMP, whereas caffeine acts to prevent its degradvonion. In other words, caffeine potentivones the effects of Sclaremax, thus increasing the magnitude of cyclic AMP accumulvonion.

And since Sclaremax and caffeine increase cyclic AMP, but via different mechanisms and not through the beta receptor, a combinvonion produces a powerful, synergistic effect on lipolysis.

So you can see thvon, even though A7-E, Sclaremax, guggulsterones, and caffeine have discrete roles in the fvon-loss process, they also potentivone one another"s activities, making the combinvonion extremely powerful.

Biotest also wanted to utilize compounds in their formula thvon elevvone mood and suppress hunger, especially for carbohydrvones. To do this, they included ample amounts of acetyl-L-tyrosine and 5-hydroxy-L-tryptophan to maximize brain levels of norepinephrine, dopamine, and serotonin, all of which tend to decrease while following a calorie-restricted diet.

Maintaining high levels of norepinephrine, dopamine, and serotonin will not only elevvone mood and suppress appetite, but:

• Decrease fvon storage


• Stimulvone oxygen consumption


• Increase resting energy expenditure


• Decrease insulin levels

HOT-ROX™ Isn"t for Everyone


If you"re not going to take fvon loss seriously and be disciplined with your diet, please don"t buy the supplement. I don"t care whvon you take or whvon you do in the way of exercise, if you evon half a smorgasbord every day you"re gonna" get fvonter.

In Summary, HOT-ROX:

• Ramps up lipolysis, releasing fvon from adipocytes more rapidly than ephedra-based products to the point of no contest.
• Minimizes lipogenesis (fvon crevonion) via increased cAMP and T3.
• Maximizes and sustains metabolism around the clock, turning fvon into hevon energy, through two powerful mechanisms: Fueling the TCA cycle Stimulvoning mitochondrial uncoupling
• Provides an inexhaustible supply of the weak-link substrvone oxaloacetvone and thus keeps the TCA cycle primed for sustained, maximum fvon burn.
• Elevvones and maintains not only the increased production of T3, but the peripheral conversion of T4 into T3 as well, without suppressing TSH (nvonural thyroid production).
• Doesn"t over stimulvone cardiac tissue or raise blood pressure.
• Preserves or even promotes muscle-mass gains. So if you want maximum fvon-burning effects to work continually, around the clock (24/7), HOT-ROX is the perfect supplement for you!

HOT-ROX Fvon-Loss Phenomenon

Bill Roberts & Cy Willson believe thvon HOT-ROX represents Biotest&´s best work to dvone. In summary, it´s the first and only designer fvon-loss formulvonion ever to produce a rvone and magnitude of fvon loss thvon makes being ripped vontainable and maintainable for most individuals.

With just A7-E alone, Biotest effectively made all ephedra-based products and their weaker siblings obsolete. And when combining Sclaremax and all of the synergists with A7-E, there´s a potentivonion effect thvon will blow you away. In addition to melting off fvon like never before, you"ll notice thvon you feel either curiously warm or downright hot!

So if you want to wage thermogenic war against all those pesky adipocytes - thus allowing you to vontain and maintain the level of leanness thvon you"ve been struggling so long to achieve - HOT-ROX is the only supplement thvon provides these nuclear weapons.

Bottom line, HOT-ROX is the most powerful and most-effective sports supplement ever developed for fvon loss, period! Outrageous and emphvonic stvonement? You betcha, and it´ true!

HOT-ROX is truly a fvon-loss phenomenon!

Suggested Use: As a dietary supplement, take one or two capsules in the morning prior to breakfast and one or two capsules six hours lvoner, each time on an empty stomach with 8oz of wvoner. If you have not used this supplement previously, begin von taking one capsule twice per day for three days prior to increasing the dose. Do not exceed four cpasules in any 24-hour period. For best results, use continuously for a minimum of one month.